Calicheamicin, Micromonospora

Bacteria called Micromonospora echinospora produce calicheamicin y/ as a natural metabolite, presumably as a chemical defense against other organisms. 

ERYTHROMYCIN D Staunton 1997 Wu 2000) high-performance production of 6-deoxyerythronolide has been achieved by fermentation of a metabolically engineered strain of Escherichia coli Pfeifer 2001 methvmvcins. calicheamicins. and pikromvcins METHYMYCIN-CALICHEAMICIN-class and pikromycin-calicheamicin-class Micromonospora echnospora CalH - Streptomyces venezuelae mutant Zhao 1999). 

Whitwam, R.E. Ahlert, J. Holman, T.R. Ruppen, M. Thorson, J.S. (2000) The gene calC encodes for a non-heme iron metalloprotein responsible for calicheamicin self-resistance in Micromonospora. J. Am. Chem. Soc., 122,1556-7. 

The enediyne antibiotics [75,76] have arrived on the scene in the 1980s with calicheamicin isolated from Micromonospora echinospora calichensis. They have a novel molecular stmc-ture which makes the enedi)me antibiotics natural prodrugs that is, the enediyne antibiotics... 

Calicheamicins, a novel family of antitumour antibiotics produced by Micromonospora echinospora ssp. calichensis, contain the part... 

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