Calculating, heparin dose

A pharmacokinetic model which describes a patienf s response to the widely used anticoagulant drug, heparin, is discussed. The model contains several unknown parameters. A patients own past data can be used to identify these parameters and thus tailor-make a model for each individual under treatment. Once such a model is available it can be used to calculate optimum dosing policies to achieve a specified therapeutic goal. 

Second, calculate the dose of heparin per hour to administer to the patient. 

Heparinization is usually recommended when coaxial catheter assembly systems are used to prevent fibrin clot formation. Initial prothrombin time, partial thromboplastin time and activation coagulation time is recommended to use as a baseline to calculate the dose of the protamine sulfate dosage when heparinization is to be reversed. Complete heparinization of the patient can be achieved with a bolus dose (50 lU/Kg) and a maintenance infusion (500 UI/Kg in 24 hours) that is initiated once the arterial access is obtained. 

Give protamine sulfate 1 mg/100 U heparin received in last 3 hours (give initial 10 mg test dose by slow IVP over 10 minutes and observe for anaphylaxis if stable give entire calculated dose by slow IVP maximum dose 100 mg)... 

Heparin is a medication that inhibits the formation of platelets and can be administered either as a subcutaneous injection or as a continuous intravenous infusion. The proper dose of heparin is always calculated using either the formula method or the ratio-proportion method. 

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