Calcium verapamil analogs

The interaction energies between an arginine side chain and the aromatic ring close to the chiral center of verapamil analogs could be correlated with their calcium antagonistic activities (n = 10 r = 0.973 s = 0.095) [899]. 

Cayl channels (L-type) are targets of calcium-channel blockers or calcium antagonists which decrease the influx of Ca + in cardiac and smooth muscle vascular cells dihy-dropyridines (nifedipine and analogs), phenylalkylamines (verapamil) and benzothiazepines (diltiazem), widely used as antihypertensive, antianginal and antiarrhythmic drugs. Cayl openers, like Bay K 8644, have been synthesized but have not found any therapeutic interest. 

Yes. Calcium channel blockers, such as verapamil, may block this process and reduce resistance. Cyclosporine and its analogs also may be effective. 

Gallopamil hydrochloride is a somewhat more potent methoxy analog of calcium channel blocker verapamil with a similar profile. It is useful in the treatment of angina and auriculeir arrhythmia. 

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