Calcium channels as possible targets for insecticides

The calcium level inside the cells is under very strict control. Opening of the voltage-gated calcium channels in the synapse, caused by the nerve impulse, triggers the release of the transmitter substance. Calcium thus has a very important role in the transmittance of the impulse. The onset of necrosis is also triggered by increased calcium concentration because many hydrolytic 

GABA Fipronil Inhibits opening of Inhibits the signals 

ACh receptor Atropine Antagonistic block, inhibiting transmission Paralysis, and reduces the effects of nicotinoids and ACh useful as an antidote against organophosphorus and carbamate poisoning 

ACh Nicotine Causes false signals Overstimulation with 

AChE Organophosphorus insecticides Carbamates Inhibits the hydrolysis of ACh, causing overstimulation of the cholinergic synapses Nicotinic and muscarinic effects 

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Calcium channels as possible targets for insecticides Summary... 

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