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Calcium channels agonist-dependent depolarization

Simons and Pocock (1987) obtained similar results in a study of lead uptake by adrenal medullary cells. They found that metal influx was stimulated by depolarizing the cells in high external K, but that the stimulated influx was blocked by methoxyverapamil (D600) with an affinity that was higher than that for blockade of Ca " influx (0.4 vs. 4.7//M). Lead uptake was stimulated by the calcium channel agonist BAY-K8644. As was seen with cadmium, these results are consistent with the notion that voltage-dependent calcium channels could be an important route for the entry of lead into cells. Pb permeation was not affected if Cl was replaced by NO, an observation consistent with the relatively low affinity of Pb " for... [Pg.65]

See other pages where Calcium channels agonist-dependent depolarization is mentioned: [Pg.253]    [Pg.226]    [Pg.56]    [Pg.436]    [Pg.242]    [Pg.184]    [Pg.73]    [Pg.263]    [Pg.19]    [Pg.66]    [Pg.56]    [Pg.184]    [Pg.678]    [Pg.248]   
See also in sourсe #XX -- [ Pg.229 ]



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