Calcium biological significance

The biological significance of these studies is that they demonstrate that the effect of say calcium ions on membrane structures could be significant. Now in biology calcium ions are distributed unevenly being at < 10-7 M inside cell and > 10-3 M outside cells. Thus the binding is much more likely to the outside of the bilayer which could cause two effects... 

Since the initial demonstration that phosphoinositide turnover is dramatically accelerated in pancreatic slices stimulated with acetylcholine (Hokin and Hokin, 1953), the biological significance of this observation has captured the imagination of investigators in diverse fields. However, it was over twenty years before the relationship between accelerated phosphoinositide turnover, intracellular calcium... 

Many QSAR studies have been published for calcium antagonists [349, 396, 746—753]. Eq. 154 was derived for verapamil-type compounds (35) [753] a chemically closely related series of compounds (36) turned out to be potent a-adrenergic antagonists (eq. 155) [753]. While it is difficult to decide on the biological significance of these multiparameter equations, one must at least consider the complexity of such drug-receptor interactions. 

The authors [77] did not address the biological significance of intracellular calcium movements in sand dollar eggs. However, release of calcium from intracellular stores is a key regulatory step in many cell processes. To the extent that eicosanoids figure in control of intracellular calcium fluxes within eggs, the work of Silver et al. [77] may touch on another fundamental eicosanoid action in animal reproduction. 

Use of biochemical and biological information for bioprocesses is also significant to the advancement of BRE. Here, the information on the signal transduction from external Ca was utilized for regulation of ginsenoside biosynthetic pathway of cultured cells of P. notoginseng. A quantitative study on the effects of external calcium and calcium sensors was conducted to... 

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