Calcitonin, glycosylation

Fraser, N. J., Wise, A., Brown, J., McLatchie, L. M., Main, M. J., and Foord, S. M. (1999). The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin-like receptor. Mol. Pharmacol. 55 1054-1059. 

Treatment of symptomatic Paget s disease of bone CAS Registry 47931-85-1 Calcitonin 1 precursor GI 115483 PID gll5483 Glycosylated Ee Calcitonin PDB ID IBZB... 

Glycosylated bile acid analogues were shown to be more effective than taurocholate in increasing the intestinal uptake of calcitonin in rats (Bowe et al. 1997). 

The most frequent posttranslational modifications for GPCRs are N-glycosylation at the N-terminus and external loop Asn-X-Ser/Thr sequences (human calcitonin receptor-like receptor [61] and un,-adrenergic receptor [62]), pabnitoylation (human dopamine Di receptor [63]), and phosphorylation ( 2 adrenergic receptor [64]). 

Hashimoto et al (36) studied the effects of glycosylation on the structure and dynamics of eel calcitonin in micelles and lipid bilayers by NMR. It was found that the glycosylated calcitonin derivatives, CT-GlcNAc and CT-M6, took the identical comformations in micelles as calcitonin itself. Therefore, the overall conformation of the peptide was not affected by the glycosylation. Similarly,... 

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