Solutions calcipotriene

Dovonex (calcipotriene solution) scalp solution 0.005%, is a colorless topical solution containing 0.005% calcipotriene in a vehicle of isopropanol (51% v/v) propylene... 

Calcipotriene (Dovonex) is a synthetic vitamin D analog used for mild to moderate plaque psoriasis. Improvement is usually seen within 2 weeks of treatment, and approximately 70% of patients demonstrate marked improvement after 8 weeks. Adverse effects occur in about 10% of patients and include lesional and perilesional burning and stinging. Calcipotriene 0.005% cream, ointment, or solution is applied one or two times a day (no more than 100 g/wk). 

Initial therapy consisting of twice daily applications of a medium strength topical corticosteroid combined with once daily topical calcipotriene should provide adequate control for this patient s localized psoriasis. A coal tar shampoo should be initiated for her scalp psoriasis with nightly application of a corticosteroid solution to recalcitrant plaques. 

Calcipotriene is an antipsoriatic agent. It is a synthetic vitamin Dj analog. In a manner similar to vitamin D, calcipotriene regulates skin cell production and development, thereby modifying the abnormal growth and production of kerati-nocytes, responsible for the scaly red patches characteristic of psoriasis (see Figure 105). Calcipotriene is indicated in the treatment of plaque psoriasis. Scalp solution topical treatment of chronic, moderately severe psoriasis of the scalp. 

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