Venlafaxine caffeine

Venlafaxine 150 mg/day did not alter the disposition of caffeine, a probe of CYP1A2 activity (34). This suggests that at therapeutic doses venlafaxine, in contrast to flu-voxamine (SEDA-22,13), does not inhibit CYP1A2. 

Klockowski PM. Effect of venlafaxine on CYPlA2-depen-dent pharmacokinetics and metabolism of caffeine. J Clin Pharmacol 1999 39(3) 252-9. 

Single-dose venlafaxine does not alter the single-dose pharmacokinetic profile of caffeine (metabolized by CYP1A2). 

For treatment-resistant patients who do not respond to SSRIs or TCAs, or to the combination of TCAs/SSRIs with benzodiazepines, other antidepressants have shown at least some beneficial effects in alleviating PD symptoms (e.g. mirtazapine, moclobemide, nefazodone, phenelzine, reboxetine, and venlafaxine). Other agents have also been reported to exert beneficial effects in PD, especially when combined with SSRIs/TCAs (lithium, pindolol, and propranolol). In cases where all treatments have failed, valproate or olanzapine should be considered.2 - ° In order to optimize treatment, patients should avoid or reduce the consumption of compounds that could potentially induce/exacerbate panic attacks (e.g. caffeine, alcohol, and nicotine) and should exercise regularly. i... 

There are isolated cases of apparent interactions between clozapine, and ampicillin, buspirone, caffeine, haloperidol, loperamide, modafinil, nefazodone, nicotinic acid, tryptophan, or vitamin C. Grapefruit juice, influenza vaccine mirtazapine, reboxetine, or venlafaxine do not appear to interact Cocaine levels may increase when taken with clozapine. 

In 15 healthy subjects venlafaxine 37.5 mg twiee daily for 3 days then 75 mg twiee daily for 4 days did not affeet the AUC or clearance of caffeine 200 mg daily (equivalent to about 3 eups of coffee). A slight but sig-nifieant decrease in the half-life from 6.1 to 5.5 hours was noted. On the basis of this study, no special precautions are needed if both drugs are taken together. 

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