Ca+2-sensing receptor

Aida, K, Koishi, S, Inoue, M, Nakazato, M, Tawata, M and Onaya, T, 1995, Familial hypocalciuric hypercalcemia associated with mutation in the human Ca(2+)-sensing receptor gene, J Clin Endocrinol Metab 80 2594-2598... 

Baron, J, Winer, KK, Yanovski, JA, Cunningham, AW, Laue, L, Zimmerman, D and Cutler, GB, Jr., 1996, Mutations in the Ca(2+)-sensing receptor gene cause autosomal dominant and sporadic hypoparathyroidism, Hum Mol Genet 5 601-606... 

Brown, EM, Gamba, G, Riccardi, D, Lombardi, M, Butters, R, Kifor, O, Sun, A, Hediger, MA, Lytton, J and Hebert, SC, 1993, Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid, Nature 366 575-580... 

Macrocyclic 25 has been constructed with pseudocryptand 26 which can be discerned within Tsien s ratiometric fluorescent sensors as the Na receptor unit. Conformational changes by 26 upon ion binding allows strong off-on PET sensing action due to the ion-induced increase of its oxidation potential. X-ray structural evidence for the Na -induced conformational changes in 26 shows decreased conjugation with a 40° twist about the C-N bond of the 2-anisidine unit. X-ray evidence is also available for similar conformational changes in the non-macro-cyclic Ca " receptor 23. A related analysis has been made for a Ag" -phenyl-azacrown ether interaction which involves a soft-soft component. ... 

Fig. 2.5 Dose-response curves of a pheromone sense cell in Ips pint (N.Y.) specialized to (S)-( + )-ipsdienol. The effect (ca. 10 times lower) of the opposite enantiomeric sample ((R)-(-)-ipsdienol) can be ascribed to the contamination (ca. 8%) of S-( + )-ipsdienol. Adding (R)-( -)- to S-( + )-ipsdienol did not increase the response to the latter, indicating no interaction at the receptor level.

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