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C/Si bioisosterism

G Ligands of the l,4 -Silaspiro[tetralin-l,4 -piperidine] Type and the Serotonin/Noradrenaline Reuptake Inhibitor Sila-venlafaxine Studies on C/Si Bioisosterism... [Pg.575]

Keywords C/Si bioisosterism, carbon/silicon switch, chirality, o ligands,... [Pg.575]

Reuptake Inhibitor Sila-venlafaxine Studies on C/Si Bioisosterism.575... [Pg.1035]

C/Si bioisosterism has been considered repeatedly due to some fundamental differences between carbon and silicon that are useful in drug design [50-52]. These include ... [Pg.137]

Finally, both fexofenadine and its sila-bioisostere exhibited similar in vitro pharmacological profiles. Evaluation of the effects in vivo of the C/Si switch, though, was not reported. [Pg.139]

See other pages where C/Si bioisosterism is mentioned: [Pg.577]    [Pg.579]    [Pg.581]    [Pg.1144]    [Pg.1159]    [Pg.577]    [Pg.579]    [Pg.581]    [Pg.577]    [Pg.579]    [Pg.581]    [Pg.1144]    [Pg.1159]    [Pg.577]    [Pg.579]    [Pg.581]    [Pg.33]    [Pg.2376]    [Pg.64]    [Pg.64]    [Pg.24]    [Pg.331]    [Pg.324]    [Pg.331]    [Pg.2376]   
See also in sourсe #XX -- [ Pg.575 ]

See also in sourсe #XX -- [ Pg.137 ]



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