C-methyl-D-erythritol kinase

Figure 9.4 Monoterpene biosynthesis in peppermint oil gland secretory cells. The enzymes involved in this pathway are (1) 1-deoxy-D-xylulose 5-phosphate synthase, (2) 2-C-methyl-D-erythritol 4-phosphate reductoisomerase, (3) 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase, (4) 4-(cytidine 5 -diphospho)-2-C-methyl-D-erythritol kinase, (5) 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, (6) isopentenyl diphosphate isomerase, (7) geranyl diphosphate synthase, (8)...

KUZUYAMA, T., TAKAGI, M., KANEDA, K, WATANABE, H, DAIRI, T., SETO, H., Studies on the nonmevalonate pathway conversion of 4-(cytidine 5 -diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5 -diphospho)-2-C-methyl-D-erythritol kinase, Tetrahedron Lett., 2000, 41, 2925-2928. 

ROHDICH, F., WUNGSINTAWEEKUL, J., LUTTGEN, H., FISCHER, M., EISENREICH, W., SCHUHR, C.A., FELLERMEIER, M SCHRAMEK, N., ZENK, M.H., BACHER, A., Biosynthesis of terpenoids 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from tomato, Proc. Natl. Acad. Sci. USA, 2000, 97, 8251-8256. 

MEP is first transformed into 4-(cytidine 5 -diphospho)-2-C-methyl-D-erythritol with the enzyme 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD, EC 2.7.7.60), followed by tire formation of 2-phospho-4-(cytidine 5 -diphospho)-2-C-methyl-D-erythritol catalyzed by the enzyme 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (ispE, EC 2.7.1.148). Later, the enzyme 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF, EC 4.6.1.12) produces 2-(3-methyl-D-erythritol 2,4-cyclodiphosphate, which is converted into... 

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