C-Branched, Amide Tris Connectivity

Since these arborols (111) are comprised of two hydrophilic groups connected by a hydrophobic linkage, they fit the simple definition of a bolaamphiphile a term derived from bolaform amphiphile, originally introduced in 1951 by Fuoss and EdlesonJ128 In 1984, when Fuhrhop and Mathieu 129 reported the synthesis and self-assembly of several bolaamphiphiles, these two-directional surfactant-like macromolecules represented a simple entrance to the bolaamphiphile field this subject has recently been highlighted1130 and reviewed.1131  

In 1985, application of this simple dendritic construction to a polymer core, specifically chloromethyl functionalized polystyrene was reported. 139 Another example of the identical procedure was reported 140 except utilizing another polymeric core backbone, derived from a functionalized vinyl ether monomer. These are very early examples of dendritic comb macromolecules. 

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