C-Acetyl. . . s. Methyl ketones

C-Acetyl... s. Methyl ketones Acetylation s. a. Acylation N-Acetylation, selective, with ketene 24,326... 

Pipe race tazine. 1 -[10-[3-[4-(2-Hydroxyethyl)-l-piperidinyljpropyl]-10H-phenothiazin-2-yt]ethanone 10-fJ-[4-(2-hydroxyethyl)piperidino)propyI]phenothiazln-2-yl methyl ketone 2-acetyl-10-[3-[4-( -hydroxyethyl)piperi-dino]propyl]phenothiazine 2-acetyl-10-[3 -[> -(2-hydroxy-ethyl)piperidino]propyl]phenothiazine PC-1421 Psymod Qutde. CmHwNjOjS mol wt 410.59. C 70.21%, H 7.37%, N 6.82%, O 7.79%, S 7.81%. Prepn Brit. pat. 861,807 (1961 to Searle). 

To a solution of 5 mmol of 1,3-diphcnyl 3-[(S )-2-mcthoxymethyl-l-pyrrolidinyl]-2-propenyl[lithium in 10 mL of tort-butyl methyl ether (prepared according to Section D. 1.1.1.2.2.3.) at 0°C. 6.25 mmol of the aldehyde (and eventually 6.25 mmol of lithium halogenide in 27 mL of leri-butyl methyl ether) are added dropwise. Stirring is continued for 2 h and 0.39 g (5.0 mmol) of acetyl chloride are added. After 2 h stirring at r.t., 10 mL of the solvent, 50 mL of diethyl ether and 10 mL of 2 N aq hydrochloric acid are added and stirring is continued for 2 h at 20 C. The organic layer is extracted with three 20 mL-portions of water and the aqueous solutions are reextracted with diethyl ether. The combined aqueous solutions are dried over Na,S04, concentrated in vacuum and the residue distilled to yield a mixture of xyn- and on/i-ketones >90% ee, determined by H-NMR with Pr(hfc)3. 

Methyl Vinyl Ketone 3-Buten-2-one A3-2 -but-enone methylene acetone acetyl ethylene 3-oxo -a -butyl-ene. C4H(0 mol wt 70.09. C 68.55%, H 8.63%, O 22.83%. CHJCOCH=CHi. Prepn by condensation of acetone and formaldehyde to 3 -keto butanol and dehydration to methyl vinyl ketone Merling Kohler, J. Soc. Chem. Ind 29> 1037 (1910) White, Haward, X Chem. Soc. 1943, 25. Prepn from vinylaoetylene Conaway, U S. pat. 1,967,225 (1934 to du Pont). For review and polymerization characteristics see 4<Vinyl Ketone Polymers in Encyclopedia of Polymer Science and Technology vol. 14 (Interscience, New York, 197]) pp 617-636. 

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