C2-heteroarylation product

Although no mechanistic rationale for the arylation reaction was put forward, kinetic isotope effect studies suggested that this transformation was not occurring via a SnAr mechanism. This seminal publication led to other C—H activation methodologies for the synthesis of C2-heteroarylated products,C2-alkenylated products, and C2-alkylated pyridine derivatives. ... 

Good functional group tolerance on the heteroaryl moiety was observed for halides, acyl, nitro, amide, ester, nitrile, and hydroxyl groups. In addition, the reaction was highly regioselective only the C2-heteroarylated product was detected. 

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