Bypass DNA polymerase

Zhou, B. L., Pata, J. D., and Steitz, T. A. (2001). Crystal structure of a DinB lesion bypass DNA polymerase catalytic fragment reveals a classic polymerase catalytic domain. Mol. CellS, 427-437. 

Broyde, S., Wang, L., Rechkoblit, O., Geacintov, N.E., and Patel, D.J. (2008) Lesion processing high-fidelity versus lesion-bypass DNA polymerases. Trends Biochem. Sci., 33, 209-219. 

Impact of Chemical Adducts on Translesion Synthesis in Replicative and Bypass DNA Polymerases From Structure to Function... 

In this connection, crystal structures of the (+) - trans-anti-1 i a P D E- N2-dG adduct in the Y-family lesion bypass DNA polymerase IV (Dpo4) (see also Chapter 15 by Chandani and Loechler) from the archaeon Sulfolobus solfataricus reveal that the favored P domain is preserved in the enzyme in this case [51], Overall, a survey of crystal structures of DNA damaged by polycyclic carcinogenic chemicals shows that structures observed in DNA duplexes in solution by high-resolution NMR methods are often observed in polymerases [37] however, the preferred P domain can be overridden by strong lesion-polymerase interactions, as was manifested in a crystal structure of a B[a]PDE-derived adenine lesion [52],... 

Nohmi, T. (2006) Environmental stress and lesion-bypass DNA polymerases. Annu. Rev. Microbiol, 60, 231-253. 

Lee, C.H., Chandani, S., and Loechler, E.L. (2006) Homology modeling of four lesion-bypass DNA polymerases structure and lesion bypass findings suggest that E. coli pol IV and human Pol k are orthologs, and E. coli pol V and human Pol r are orthologs. 

Fujii, S., and Fuchs, R. P. (2004). Defining the position of the switches between replicative and bypass DNA polymerases. EMBO. /. in press. 

Error-bypass DNA polymerases A new class of recently discovered DNA polymerases in both prokaryotes and eukaryotes which are more tolerant of improper base pairing and may function in maintaining genomic continuity when damaged DNA bases have not been repaired. 

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