2-Butyne-l,4-diol diacetate

The 2-aryl-substituted 4-phenyloxazole 144 has been used in the synthesis of the pharmacologically active tetrahydrofuran lignan natural products (Fig. 3.43). Refluxing a mixture of 144 with 2-butyn-l,4-diol diacetate in the presence of sodium carbonate and hydroquinone for 22 h provided an 89% yield of the 2,3,4-trisub-stituted furan 145. Elaboration of 145 by hydrolysis of the diacetate and selective oxidation of the 4-carbinol then afforded the lignan 146 as a mixture of diaster-eomers after three additional steps. ... 

MERCURIC DIACETATE (1600-27-7) Light and heat can cause decomposition. May react violently or form sensitive explosive compounds with 2-butyne-l,4-diol, fluoroacetylene, oi-nitroguanidine, 5-nitrotetrazol. Incompatible with ammonia, hydrozoic acid, methyl isocyanoacetate, sodium acetylide, sodium peroxyborate, trinitrobenzoic acid, urea nitrate. 

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