2-Butenylene dicarbamate cyclization

Intramolecular asymmetric allylic substitution reactions have been applied to the synthesis of optically active cyclic compounds. The high efficiency of the dihydroxylated ferrocenylphosphine 8b has been shown in the cyclization of 2-butenylene dicarbamates 52 to form optically active 4-vinyl-2-oxazolidones 53, which are... 

The palladium-catalyzed intramolecular addition of N—H to 2-butenylene dicarbamates leads to cyclization. Optical activity can be induced by chiral fer-rocenylphosphines carrying amino substituents with hydroxyalkyl side-chains such as (45). The reaction proceeds via 7r-allyl palladium complexes. The primary product can be hydrolyzed to give optically active aminoalcohols (Scheme... 

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