Butenolides by Passerini-3CR and the Horner-Emmons-Wadsworth Reaction

4 Butenolides by Passerini-3CR and the Horner-Emmons-Wadsworth Reaction 

Another synthesis of the butenolide core was reported by the Domling group [54], The reaction between arylglyoxals, isocyanides, and a-diethylphosphonoalkanoic 

Ar = Ph, 2-thienyl, 4-HOC6H4, 2-naphthyl, 4-PhC6H4 R1 = H, Ph, 4-FC6H4, 3-MeOC6H4 R = n-Bu, f-Bu, allyl, cyclohexyl, f-Bu02C(Me)CH, f-Bu02C(CH2)2, Me02C(/-Bu)CH 

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