Buspirone interaction with itraconazole

The interaction of itraconazole with the active l-(2-pyrimidinyl)-piperazine metabolite of buspirone has been studied after a single oral dose of buspirone 10 mg... 

The interaction of itraconazole with the active l-(2-pyri-midinyl)-piperazine metabolite of buspirone has been studied after a single oral dose of buspirone 10 mg (66). Itraconazole reduced the mean AUC of the metabolite by 50% and the by 57%, whereas the mean AUC and Cmax of the parent drug were increased 14.5-fold and 10.5-fold respectively. Thus, itraconazole caused relatively minor changes in the plasma concentrations of the active piperazine metabolite of buspirone, although it had major effects on the concentrations of buspirone after a single oral dose. 

Kivisto KT, Lamberg TS, Neuvonen PJ. Interactions of buspirone with itraconazole and rifampicin effects on the pharmacokinetics of the active l-(2-pyrimidinyl)-pipera-zine metabolite of buspirone. Pharmacol Toxicol 1999 84(2) 94-7. 

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