Buspirone glucuronide

The concept can be illustrated by the identification of the metabolites of the anxiolytic drag buspirone [1, 12]. Buspirone (Figure 10.2b) is considered as a combination of three subgroups the azaspirone decane dione (A), the butyl piperazine (B), and pyrimidine (P). Whereas buspirone itself is annotated at A-B-P, a metabolite with a substitution in the pyrimidine ring can be indicated as A-B-P. It was found that in buspirone the azaspirone decane dione and the pyrimidine part of the molecule are prone to (multiple) substitution, such as hydroxylation, hydroxylation and methoxylation, and glucuronidation. The loss of the complete substructure is also observed. In this way, a total number of 26 buspirone metabolites were identified and categorized. 

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