Buserelin preparations

Buserelin and naferelin are available as intranasal preparations. As these need daily dosing they are not commonly prescribed, as psychologically the patient is constantly reminded of the disease. 

Uekama, K., Arima, H., Me, T., et al. (1989) Sustained release of buserelin acetate, a luteinizing hormone-releasing hormone agonist, from the injectable oily preparation utilizing ethylated P-cyclodextrin. J. Pharm. Pharmacol 41 874-876. 

In preparations intended to obtain a systemic effect a spray solution is the favourite dosage form, because it enables accurate dosing. Examples of nasal preparations for systemic purpose are listed in Table 8.2. Examples of licensed preparations are nasal sprays with buserelin, fenta-nyl and vaccines (e.g. against airway infections) [8]. 

When used correctly, nasal drops and sprays will not come into contact with the taste buds, but nevertheless they can give a sensation of taste [23]. This is easy to understand, as the olfactory organ plays an important role in the experience of taste. The clearance through the nasopharynx can be another cause, as a bitter taste is mainly observed at the rear of the tongue. Usually nasal preparations do not contain any flavouring agents. A side effect of especially nasal sprays may be a change in the users sensation of smell and taste. Examples are nasal sprays with fluticasone and with buserelin (Suprefact ). 

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