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Fluvoxamine Buprenorphine

Iribarne C, Picart D, Dreano Y, Berthou F. In vitro interactions between fluoxetine or fluvoxamine and methadone or buprenorphine. Fundam Clin Pharmacol 1998 12(2) 194-9. [Pg.67]

Fluoxetine has slightly reduced the analgesic effects of morphine and oxycodone. Buprenorphine metabolism is inhibited by fluvoxamine in vitro, but this is probably not clinically relevant... [Pg.1220]

Fluvoxamine inhibited the metabolism of buprenorphine in vitro, but the inhibition was not thought sufficient to be clinically significant. ... [Pg.1220]

Fluoxetine inhibits the activity of the cytochrome P450 isoenzyme CYP2D6 within the liver so that the metabolism of oxycodone to an aetive metabolite oxymorphone is reduced. The metabolism of hydroeodone and similar opioids may also be affected by CYP2D6 inhibitors, see Opioids Codeine and related drugs + Quinidine , p.l84. Buprenorphine and morphine are not metabolised by CYP2D6, so their metabolism would not be expeeted to be affected by fluoxetine. Buprenorphine is metabolised by CYP3A4 and so fluvoxamine might be expected to inhibit its metabolism to some extent. [Pg.1221]

See other pages where Fluvoxamine Buprenorphine is mentioned: [Pg.21]    [Pg.35]    [Pg.48]    [Pg.60]    [Pg.124]    [Pg.137]    [Pg.142]    [Pg.204]    [Pg.228]    [Pg.384]    [Pg.414]    [Pg.459]    [Pg.489]    [Pg.590]    [Pg.622]    [Pg.659]    [Pg.745]    [Pg.801]    [Pg.836]    [Pg.841]    [Pg.845]    [Pg.888]    [Pg.958]    [Pg.979]    [Pg.1002]    [Pg.1142]    [Pg.1171]    [Pg.1189]    [Pg.1205]    [Pg.1210]    [Pg.1286]    [Pg.1312]    [Pg.1372]    [Pg.1491]    [Pg.1221]    [Pg.21]    [Pg.35]    [Pg.48]    [Pg.60]    [Pg.124]    [Pg.137]    [Pg.142]    [Pg.204]    [Pg.228]   
See also in sourсe #XX -- [ Pg.1220 ]



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Buprenorphine

Fluvoxamine

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