Bulk nanoemulsion

The in-vitro drug release kinetic profile of clofibride from a nanoemulsion was determined using two different kinetic techniques the bulk equilibrium reverse dialysis sac technique, and the centrifugal ultrafiltration technique at low pressure. The former technique was shown to be inadequate for in-vitro kinetic comparison purposes as a result of drug diffusion limitations through the dialysis membrane. The latter technique yielded rapid in-vitro release profiles of clofibride from the nanoemulsion under perfect sink conditions. The kinetic results clearly exclude the use of a nanoemulsion as a colloidal controlled release delivery systems for any administration route where perfect sink conditions should prevail. ... 

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