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Matrices, bulk erosion, drug release rate

A much more desirable erosion mechanism is surface erosion, where hydrolysis is confined to a narrow zone at the periphery of the device. Then, if the drug is weU-immobihzed in the matrix so that drug release due to diffusion is minimal, the release rate is completely controlled by polymer erosion, and an ability to control erosion rate would translate into an ability to control dmg delivery rate. For a polymer matrix that is very hydrophobic so that water penetration is limited to the surface (thus Hmiting bulk erosion), and at the same time, allowing polymer hydrolysis to proceed rapidly, it should be possible to achieve a drug release rate that is controlled by the rate of surface erosion. Two classes of biodegradable polymers successfully developed based on this rationale are the polyanhydrides [31] and poly (ortho esters) [32], the latter of which is the subject of this chapter. [Pg.1491]

See other pages where Matrices, bulk erosion, drug release rate is mentioned: [Pg.2247]    [Pg.7]    [Pg.128]    [Pg.69]    [Pg.80]    [Pg.176]    [Pg.55]    [Pg.503]    [Pg.417]    [Pg.5]    [Pg.128]    [Pg.266]    [Pg.267]    [Pg.332]    [Pg.1005]    [Pg.179]    [Pg.198]    [Pg.172]    [Pg.15]    [Pg.256]    [Pg.111]    [Pg.444]    [Pg.165]    [Pg.287]    [Pg.1248]    [Pg.11]    [Pg.53]   
See also in sourсe #XX -- [ Pg.387 ]



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