Building-block strategy

Another example of nitrogen-based ligands can be found in a new family of ligands that were developed in solution through the use of solid-phase extractions (SPE) (Scheme 22) (49). In this approach, a building block strategy was taken in... 

Fessner W-D (1992) A Building Block Strategy for Asymmetric Synthesis The DHAP Aldolases. In Servi S (ed) Microbial Reagents in Organic Synthesis. Kluwer Academic, Dordrecht, vol. 381, p 43... 

Fig. 12.6 Synthetic DNA building block strategy for the modification of DNA bases by chromophores. Bx = base Ch = chromophore.

These observations led us to propose a building-block strategy toward the preparation of CB[n] compounds [4,5] which was subsequently demonstrated experimentally in the synthesis of CB[n] derivatives and analogs [34,37,38]. Kim s synthetic advance in developing the direct per-hydroxylation of CB[5]-CB[8] allowed his group to prepare a wide range of per-functionalized CB[5] and CB[6] derivatives and to use them in new applications such as synthetic ion-channels and supramolecular vesicles [39-41]. 

The building block strategy 1 is currently much more distinct than the all in one approach but this is rather related to the fact that new radiopharmaceuticals are not in the stage of clinical development than due to the impossibility of proceeding from option 1 to 2 for the currently available complexes. 

An elegant synthesis that combined advantages of the polymer-supported technology and convergent building-block strategy was applied to the synthesis of a hex-asaccharide 274 (Scheme 55).247 The key feature of this assembly is the use of an anomerically connected spacer-linker that can be removed under unique reaction conditions. This approach also allows flexible manipulation with the remaining... 

Scheme 13 Assembly of a dodecasaccharide by the building block strategy on the solid phase.

MO oS oO o(OH)io(H20)5] Molecular Ring Forthe Building Block Strategy,/. Phys. Chem. Solids 2000, submitted. 

Three different types of building block strategies were developed for the efficient synthesis of peptoids as schematically shown in Scheme 2.4.1 (Approaches A-C)P ... 

Xiao, J. Zhang, X. Wang, D. Yuan, C. Synthesis of trifluoromethyltetrazoles via building block strategy. J. Fluorine Chem. 1999, 99, 83-85. 

Chemical synthesis has traditionally relied on a building block strategy where relatively few chemicals are identified as primary building blocks that are subsequently transformed into secondary building blocks and other materials of industrial interest. Of the top 50 large volume chemicals produced annually in the United States, the 28 organic compounds on the list are derived from only 8... 

Nickelsen K (2009) The construction of a scientific model. Otto Warburg and the building block strategy. Stud Hist Philos Biol Biomed Sci 40 73-86... 

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