Building Block Preparation Patents

Mention of chirality in dendritic architectures can be traced back to patents of Denkewalter et al., which describe the construction of peptide-like dendritic structures from L-lysine units [1]. In spite of the demanding nature of some of these syntheses, numerous chiral dendritic structures have meanwhile been prepared and characterised [2]. This cannot be explained solely by the somewhat academic interest in the effect of chiral monomeric building blocks on the chirality of the overall molecule. The prospect of using chiral dendrimers as model... 

In addition to the phosphorus ylide building blocks which are employed in industrial processes for the preparation of carotenoid terpenes, a large number of phosphorus ylides or phosphonium salts have been developed for laboratory syntheses of natural carotenoids. The monograph Carotenoids by O. Isler7) contains an extensive summary of the examples described in the literature and in the patent literature. 

The chemical pool in soeening Ubraties must be enriched. As companies concentrate on similar targets, with sCTeening libraries acquired from the same commercial vendors or prepared in-house with automated synthesis from common building blocks, the novelty and patent problem iUCTeases. Compound novelty is a neglected issue that deserves urgent attention. 

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