Bronchodilators Other Drugs Used in Asthma

Bronchial hyperreactivity Pathologic increase in the bronchoconstrictor response to antigens and irritants caused by broixihial inflammation 

IgE-medlated disease Disease caused by excessive or misdirected immune response mediated by IgE antibodies. Example asthma 

Mast cell degranulatlon Exocytosis of granules from mast cells with release of mediators of inflammation and bronchoconstriction 

Phosphodiesterase (PDE) Enzyme that degrades cAMP (active) to AMP (inactive) 

Tachyphylaxis Rapid loss of responsiveness to a stimulus, eg, a drug 

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