Bronchi epithelium

McDowell EM, Barrett LA, Glavin F, Harris CC, Trump BF (1978) The respiratory epithelium. I. Human bronchus. J Natl Cancer Inst 61(2) 539-549. 

Roy, M. J., Ruiz, A., and Varvayanis, M. (1987). A novel antigen is common to the dome epithelium of gut- and bronchus associated lymphoid tissues. Cell Tissue Res. 248, 635-644. 

Fig. 3. Immunohistochemical expression of (a) hK7 by the epithelium of eccrine glands of the skin (monoclonal antibody, clone 73.2), (b) hK13 by the epithelium of the bronchus (monoclonal antibody, clone IIC1), (c) hK5 by the ductal epithelium of the parotid gland (polyclonal antibody), (d) hK7 by the esophageal glands (monoclonal antibody, clone 73.2), (e) hK13 by the gastric mucosa (monoclonal antibody, clone 2-17), (f) hK6 by the large intestine mucosa (polyclonal antibody), (g) hK10 in an islet of Langerhans in the pancreas (monoclonal antibody, clone 5D3), (h) hKll by the epithelium of the urinary tubuli (monoclonal antibody), (i) hKll by a papillary renal cell carcinoma (monoclonal antibody).

The bronchus is a tubular structure that brings air into the alveoli. It is lined with pseudostratified columnar epithelium surrounded by a thin lamina propria containing fine collagen and elastic fibers. A thin layer of smooth muscle surrounds the lamina propria. Glands are found in the submucosa and hyaline cartilage and the pulmonary arteries are found in the outer layer (adventitia). 

Pulmonary epithelium at three principal levels bronchus, bronchiolus and alveolus... 

M cells are found not only in the intestinal tract, but also in the respiratory epithelium overlying bronchus-associated lymphoid tissue. The studies of Park and Simpson (2003) indicate that M cells are not the major players in transepithelial transport of toxin across the respiratory epithelium. Additional studies directly investigating the absorption of inhaled BoNTs do not exist. 

Maggj, C.A., Patacchini, R., Perretti, F. etal. (1990). The effect of thiorphan and epithelium removal on contractions and tachykinin release produced by activation of capsaicin-sensitive aflferents in the guinea-pig isolated bronchus. Naunyn Schmiedeberas Arch. Pharmacol. 341, 74-79. 

Fig. 6. Lung of a vitamin A-deficient rat, showing focal replacement of the columnar ciliated epithelium of bronchus by stratified keratinizing epithelium, and infiltration of submucosa.

Becci PJ, McDowell EM, Trump BF. The respiratory epithelium. II. Hamster trachea, bronchus, and bronchioles. JNatl Cancer Inst 1978 61 551-561. 

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