Bromocriptine hypertension with

Anonymous. Postpartum hypertension, seizures, strokes reported with bromocriptine. FDA Drug Bull 1984 14(1) 3. ... 

B. Bromocriptine intoxication may present with hallucinations, paranoid behavior, hypertension, and tachycardia. Involuntary movements, hallucinations, and hypotension are reported with pergolide. 

A healthy postpartum woman taking bromocriptine developed very severe headache and marked hypertension after also taking phenylpropanolamine. Similarly another woman developed seizures with cerebral vasospasm, and a third developed a severe headache, hypertension and severe cardiac dysfunction after also taking isometheptene. A further patient taking bromocriptine developed psychosis when pseudoephedrine was added. 

Not understood. Severe hypertension occasionally occurs with either bromocriptine or phenylpropanolamine given alone. Shortly after giving birth some individuals show increased vascular reactivity, and it could be that all of these factors conspired together to cause these adverse effects. Psychosis occasionally occurs after giving birth or on bromocriptine alone, so that in the latter case the addition of pseudoephedrine may have been coincidental. ... 

Simple derivatives of ergopeptines include dihydroergotamine (with a saturated D-ring) for the treatment of migraines and dihydroergotoxine for the treatment of hypertension (11). Also, bromocriptine, derived from ergocryptine by bromination at C(2), is used in treatment of Parkinsonism. Bromocriptine is also effective in cases of hyperprolactinaemia (104), a condition that can result in... 

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