Foods Bromocriptine

Bromocriptine (Parl el) [Antiparkinsonian Agent/Dopamine Receptor Agonist] Uses Parkin on Dz, hyperprolactinemia, acromegaly, pituitary tumors Action Direct-acting on the striatal dopamine receptors X prolactin secretion Dose Initial, 1.25 mg PO bid titrate to effect, w/ food Caution [B, ] Contra Severe ischemic heart Dz or PVD Disp Tabs, caps SE X BP, Raynaud phenomenon (vasospastic disorder resulting in discoloration of the fmgers/toes), dizziness, N, hallucinations Interactions T Effects W/ erythromycin, fluvoxamine, nefazodone, sympathomimetics, antihypertensives X effects W/ phenothiazines, antipsychotics EMS Monitor BP may cause intolerance to EtOH OD May cause NA, severe hypotension give IV fluids symptomatic and supportive... 

The most common adverse effects of bromocriptine therapy include central nervous system symptoms such as headache, lightheadedness, dizziness, nervousness, and fatigue. Gastrointestinal effects such as nausea, abdominal pain, or diarrhea also are very common. Some patients may need to take bromocriptine with food to decrease the incidence of adverse gastrointestinal effects. Most adverse effects are seen early in the course of therapy and tend to decrease with continued treatment. Bromocriptine may cause thickening of bronchial secretions and nasal congestion. There have been rare cases of psychiatric disturbances, pleural diseases, and an erythromeMgic syndrome... 

Food did not alter the pharmacokinetics of bromocriptine, cabergoline or lisuride. These dopamine agonists are usually taken with food to try and improve their tolerability. 

Kopitar Z, Vrhovac B, Povsic L, Plavsic F, Francetic I, Urbancic J. The effect of food and metoclopramide on the pharmacokinetics and side effects of bromocriptine. EurJDrugMetab Phamacokinet ( 99 ) 16, 177-81. 

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