3-Bromo-2-methylpropanoic acid

Azido-2-methylpropanoic Add a-Azido Acids from a-Bromo Adds and NaN3 i i 2-Bromo-2-methylpropanoic acid (4.96 g, 29.7 mmol) and NaNj (2.88 g, 44.3 mmol) were mixed in dry DMF (50mL) and stirred under argon for 2d. The mixture was concentrated, redissolved in HjO (30 mL) and acidified to pH 2 with 3 M HCl. The aqueous phase was extracted with CHCI3 (3 x 30 mL) and the organic phase was dried, concentrated, and purified by vacuum liquid chromatography (VLCI " ) (AcOH/EtOAc/heptane 5 20 75) yield 2.68 g (70%). 

C4H6F3N02 2-amino-4,4,4-trifluorobutyric acid 15960-05-1 25.00 1.3293 2 3072 C4H7Br02 2-bromo-2-methylpropanoic acid 2052-01-9 60.00 1.4969 1... 

C4H7Br trans-1 -bromo-1 -butene 32620-08-9 367.85 32.331 1,2 3139 C4H7CI02 2-chloro-2-methylpropanoic acid 594-58-1 406.80 35.006 2... 

In 1909, Kay reported the preparation of a small quantity of the levorotatory potassium salt of this saccharinic acid from d-a-methylisoserine (XLV). Treatment of d-a-methylisoserine (XLV) with nitrosyl bromide gave 3-bromo-2-hydroxy-2-methylpropanoic acid (XLVI). The latter, on... 

Derivatives of clofibric acid were used in earlier times as hyperlipidemia-controlling drugs. Currently more interest is shown in the synthesis of 2-methyl-2-aryloxypropanoic acids because these classes of compounds are being considered as possible remedies for type II diabetes. The earlier GSK process involves reacting 2-bromo-2-methylpropanoic acid with a phenolic compound at 50°C, where both compounds are suspended in 2-butanone solvent. The acid is expensive, and large volumes of the organic solvent are also required. 

Bromo-2-methylpropanoic acid a-Bromoisobutyric acid CgHgBrOg 2052-01-9 167.002 cry (peth) 48.5 199 1.4969"" ... 

Block copolymers containing PMeVE and poly(tert-Bu acrylate), polyfacrylic acid), poly(Me acrylate) or polystyrene, have been prepared by Du Prez et al. [249] by the use of a novel dual initiator 2-bromo-(3,3-diethoxy-propyl)-2-methylpropanoate. In the first step, the living cationic homopolymerization of MeVE is performed with the acetal end group of the dual initiator as initiating site or by the ATRP... 

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