1- Bromo-2- acetylenes phenylboronic acids

Heck and Suzuki coupling reactions with bromo-oxepine 65 afforded 2-deoxy-2-alkyl/aryl septanosides. For example, Heck reaction of 65 with acrylates and styrene led to a high yield of coupled products groups as 86, whereas the use of a-methyl styrene furnished 87, in which the exo-cyc ic double bond isomerized to a terminal double bond. Suzuki coupling reaction with substituted phenylboronic acid led to 2-deoxy-2-C-aryl septanoside derivatives 88 in good yields. On the contrary, Sonogashira coupling reaction of 65 with acetylenes furnished 2-deoxy-2-C-alkenyl septanoside 89 (Scheme 13.24). 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

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