Bromine Folic acid

Acylation of 2-methylpyrido[2,3-d]pyrimidines with anhydrides gives 2-acylmethyl derivatives (67), whilst bromination to the 7-bromomethyl derivative has been reported for 7-methylpyrido[3,2-d]pyrimidines (56JCS4433) in a synthesis of potential folic acid antagonists. 

Fluorescence stabilization, porphyrins la 100-101 Fluorophors la 57 Flupentixol lb 354 Fluphenazine la 104 lb 354-356 Fluspirilen lb 354 Fluvalinates lb 86 Foam bath, brominated la 64 Folic acid la 223,225 Folin-Ciocalteu s reagent lb 180 Folin s reagent lb 321 Formaldehyde la 299,351 -, vapor la 86 Formazan lb 65... 

Pyrazino[2,3-c][l,2,6]thiadiazines are 2-thiapteridines, and their 2,2-dioxide derivatives (276) have been used in the preparation of 7-folic acid analogues (279). The latter had no biological activity, however. In the synthesis, the 7-methyl group of derivatives (276) is first brominated with pyridinium... 

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