Bromide secretion

Intranasal anticholinergic agents (e.g., ipratropium) reduce the severity and duration of rhinorrhea but have no effect on other nasal symptoms.11,12,21 Ipratropium reduces cholinergic hyperreactivity and cholinergically mediated histamine- and antigen-induced secretion. Intranasal ipratropium acts locally, with only minimal systemic absorption. Clinical trials demonstrated that ipratropium bromide 0.3% reduced rhinorrhea in adults and children with PAR.11,12 Intranasal ipratropium is an option for patients in whom rhinorrhea is refractory to topical intranasal corticosteroids and/or antihistamines.8,12 Intranasal ipratropium is available only by prescription, and the dose is two sprays nasally two to three times daily.15 Adverse effects are minimal, but dry nasal membranes have been reported.11,12... 

Ipratropium bromide (nasal) has antisecretory properties and, when applied locally, inhibits secretions from the serous and seromucous glands lining the nasal mucosa. Pharmacokinetics ... 

P14. Plununer, K., Burke, J. V., and Bradford, S. C., The effect of methantheline bromide (Banthine) on the insulin induced secretion of gastric acid, mucoproteose and mucoprotein Physiological implications. Gastroenterology 18, 218-223 (1951). 

The tetracyclic precursor 9 of cerorubenic acid III (a principal component of secretions produced by the scale insect Ceroplastes rubens Maskell, which plays an important role in communication between these wasps) is prepared by stereospecilic addition of vinylmagnesium bromide to ketone 6 to give 7 and anionic oxy-Cope rearrangement by heating 7 with excess potassium hexamethyldisilazanideI093. 

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