Broken wing-conformation

Fig. 21. Molecular modelling (A,B) of rabbit serotransferrin glycan and (C) of human lactotransferrin [192, 210,275] (A) 3D structure of rabbit serotransferrin (B) interaction of rabbit serotransferrin glycan in a broken-wing conformation with a peptide segment (amino acids 254 to 271) in an a-helix conformation, 7,7, Al-acetylneuraminic acid residues (see Fig. 6A). (C) 3D structure of human lactotransferrin. Arrows indicate the position of glycans.

Montreuil has proposed the terms T -, Y -, bird and broken wing shape for the description of the conformations of AT-type oligosaccharides [154, 155]. These terms, although illustrative, highly simplify the conformational orientation of the different parts of the molecule with respect to the others. The more elaborate characterization of the molecule via its dihedral angles is required to describe the conformers at the glycoside bonds adequately, because within each of the families of conforma-... 

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