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Broad gradient conditions, HPLC

Figure 8.2. The first HPLC chromatogram of a drug substance analyzed with generic broad gradient conditions. The active pharmaceutical ingredient (API) elutes at %B of 35-40% of acetonitrile, showing presence of several impurities between 5 and 9min. Figure 8.2. The first HPLC chromatogram of a drug substance analyzed with generic broad gradient conditions. The active pharmaceutical ingredient (API) elutes at %B of 35-40% of acetonitrile, showing presence of several impurities between 5 and 9min.
Oligomeric additives with broad MWD tend to be a problem in conventional HPLC conditions. In cases where no interest exists in the oligomer distribution it is common practice to solve the problem by creating a uniform structural unit useful for analysis. For example, isocratic (or gradient) LC-UV was used for the determination of the polymeric light stabiliser Tinuvin 622 in polyolefins using dissolution (toluene)/derivatisation (TBAH)-precipitation (alcohol) the diol formed was quantitatively determined by NPLC [653]. [Pg.248]

C Elution as a broad peak using a linear gradient. HPLC conditions see A gradient... [Pg.539]

See other pages where Broad gradient conditions, HPLC is mentioned: [Pg.148]    [Pg.17]    [Pg.105]    [Pg.202]    [Pg.109]    [Pg.194]    [Pg.248]    [Pg.90]    [Pg.305]    [Pg.444]    [Pg.24]    [Pg.239]    [Pg.372]   


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