Bringing acids and bases together to create amides

Bringing acids and bases together to create amides 

Amides contain an acid portion and an amine portion. However, unlike the formation of an ester, the reaction of a carboxylic acid with an amine is not an efficient method for preparing an amide, because, as you see in this section, the simple reaction of an acid (carboxylic acid) with a base (amine) causes interference. Fortunately, methods similar to many of the other ester synthesis methods are useful in the synthesis of amides. 

The formation of an amide by the reaction of an acid chloride with ammonia. 

The preparation of phenacetin by the reaction of an amine with an acid anhydride. 

The reaction of ammonia with a carboxylic acid to eventually form an amide. 

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