Brain endogenous antioxidant

Table 9.1 Antioxidant enzymes and endogenous antioxidant in brain tissue...

Karibe H., Chen S. F., Zarow G. J., et al. (1994) Mild intraischemic hypothermia suppresses consumption of endogenous antioxidants after temporary focal ischemia in rats. Brain Res. 649,12-18. 

Heaton, M.B., Paiva, M., Madosky, 1., Mayer, J., and Moore, D.B. (2003). Effects of ethanol on neurotrophic factors, apoptosis-related proteins, endogenous antioxidants, and reactive oxygen species in neonatal striatum relationship to periods of vulnerability. Dev. Brain Res. 140 237-252. 

There is also evidence that normal in vivo concentrations of ascorbic acid are sufficient to protect against lipid peroxidation. With physiological concentrations of iron and tocopherol, a 50% inhibition of lipid peroxidation was obtained with 410 xM ascorbic acid this was reduced to 90 xM when tocopherol content was increased fivefold. Only when endogenous tocopherol was decreased to 20% was the in vivo intracellular ascorbic acid concentration too small for antioxidative protection of lipids (Reiber et al., 1994). Therefore, there is a large antioxidant capacity in brain cells that is additionally supported by a very efficient ascorbic acid homeostasis within the brain. 

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