Bradykinin dimer

Fig. 7. Arrhenius plot for the dissociation of bradykinin dimer ions (2M+2H)2+. Rate constant k in s 1, temperature T in K...

Fig. 6a-c. Ion mobility spectra of bradykinin ions at m/z=1061 a the two features seen at 441 K are the singly protonated monomer (M+H)+ and the doubly protonated dimer (2M+2H)+ b at a cell temperature of 463 K the dimer dissociates into two monomer units accounting for the fill-in between the two peaks c at 510 K all of the dimer ions have disappeared upon exiting the cell... 

One final development worthy of note here is the development of novel anticancer agents that are dimeric bradykinin analogs. There has been a long-term interest in cross-linked kinin analogs as both agonists and antagonists of GPCRs... 

Chan, D., Gera, L., Stewart, J., et al. (2002) Bradykinin antagonist dimer, CU210, inhibits the growth of human lung eaneer eell lines by a biased agonist mechanism. Proc. Natl. Acad. Sci. USA 99, 4608 613. 

Lifshitz, C. (2004) A Review of Gas-phase H/D Exchange Experiments the Protonated Arginine Dimer and Bradykinin Nonapeptide Systems. Int. J. Mass Spectrom. 234 63-70. 

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