Bovine serum albumin asymmetric catalyst

Enantioselective Reductions. NaBH4 has been employed with less success than LiAULt or BH3 in enantioselective ketone reductions. Low to moderate ee values have been obtained in the asymmetric reduction of ketones with chiral phase-transfer catalysts, chiral crown ethers, -cyclodextrin, and bovine serum albumin. On the other hand, good results have been realized in the reduction of propiophenone with NaBH4 in the presence of isobutyric acid and of diisopropylidene-D-glucofuranose (ee = 85%), " or in the reduction of cr-keto esters and -keto esters with NaBHa-L-tartaric acid (ee >86%). ... 

Some enzymes are well known to show high chiral recognitions and have been used as asymmetric catalysts in organic synthesis. A few proteins, such as bovine serum albumin, a i-acid glycoprotein, and ovomucoid, have also been used as CSPs for HPLC [32-34]. These CSPs can resolve many chiral drugs. Protein-based CSPs are often not stable because they change their conformation depending on the conditions such as solvents and temperature. The proteins contain many different... 

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