Bouveault-Locquin

BOUVEAULT - LOCQUIN Aminoacid synthesis Synthesis of aminoacids from mahnale esters by nrtrosation... 

BOUVEAULT LOCQUIN ArtiinoacKJsynthesis Synthesis of aminoacids from magnate esters by nrtrosatlon... 

BOUVEAULT Aldehyde synthesis 39 BOUVEAULT - BLANC Reduction 44 BOUVEAULT - HANSLEY - PRELOG - STOLL Acyloin synthesis 44 BOUVEAULT - LOCQUIN Amtnoactd synthesis 45... 

BOUVEAULT - LOCQUIN Aminoacidsynthesis Synthesis ot aminoacids from malonate esters by nitrosation... 

Improved Bouveault-Locquin synthesis— a-Ketocarboxylic acids and esters s. 16, 230... 

Bouveault-Blanc reduction, modified 16, 89 Bouveault-Locquin synthesis, improved 16, 230 Bradsher reagent 5, 642 V. Braun reaction 17, 625 Bridges s. a. Ethenylene bridges, Ring —... 

Bouveault and Locquin have also synthesised leucine by the reduction of a-oximinoisobutylacetic acid, which was prepared in a similar way to the isomeric compound from which they obtained isoleucine. 

Further proof that isoleucine has this constitution was given by Bouveault and Locquin in 1906. They synthesised it from sec. butyl-acetoacetic ester, which they prepared from sec. butyliodide and sodium-acetoacetic ester —... 

L. Bouveault et R. Locquin. Hydrogenation des ethers a-oximides synthese des homo-logues du Glycocolle et de leurs ethers. Bull. Soc. Chim., 1904, [iii], 31, 1176-1180. L. Bouveault et R. Locquin. Nouvelle synthise de la leucine racemique. Bull. Soc. 

The method of Bouveault and Locquin,9 which consists of oxidizing cyclohexanol with concentrated nitric acid, has been found to be the most useful for laboratory preparation. 

This reaction was first reported by Bouveault and Blanc in 1903, and was further extended by Bouveault and Locquin. It is the synthesis of symmetrical a-hydroxy ketones via the reductive condensation of esters in an inert solvent in the presence of sodium. Since symmetrical a-hydroxy ketones, the aliphatic analogs of benzoins, are generally known as acyloins, the formation of a-hydroxy ketones from esters is simply referred to as acyloin condensation. In a few cases, it is also referred to as acyloin reaction." For the individual acyloin, the name is derived by adding the suffix oin to the stem name of corresponding acid, e.g., acetoin prepared from acetate. The most common method used to make acyloin is the reductive condensation of aliphatic esters with sodium in inert solvents, such as ether, xylene or even in liquid NH3 The yield of this reaction can be greatly improved when trimethylchlorosilane presents." " Intromolecular acyloin condensation from aliphatic diesters affords cyclic ketones of different ring sizes. 

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