Bouveault-Locquin synthesis improved

Bouveault-Blanc reduction, modified 16, 89 Bouveault-Locquin synthesis, improved 16, 230 Bradsher reagent 5, 642 V. Braun reaction 17, 625 Bridges s. a. Ethenylene bridges, Ring —... 

Improved Bouveault-Locquin synthesis— a-Ketocarboxylic acids and esters s. 16, 230... 

This reaction was first reported by Bouveault and Blanc in 1903, and was further extended by Bouveault and Locquin. It is the synthesis of symmetrical a-hydroxy ketones via the reductive condensation of esters in an inert solvent in the presence of sodium. Since symmetrical a-hydroxy ketones, the aliphatic analogs of benzoins, are generally known as acyloins, the formation of a-hydroxy ketones from esters is simply referred to as acyloin condensation. In a few cases, it is also referred to as acyloin reaction." For the individual acyloin, the name is derived by adding the suffix oin to the stem name of corresponding acid, e.g., acetoin prepared from acetate. The most common method used to make acyloin is the reductive condensation of aliphatic esters with sodium in inert solvents, such as ether, xylene or even in liquid NH3 The yield of this reaction can be greatly improved when trimethylchlorosilane presents." " Intromolecular acyloin condensation from aliphatic diesters affords cyclic ketones of different ring sizes. 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

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