Botanical Products and Digoxin

CHINESE BOTANICAL PRODUCTS AND DIGOXIN Crataegus pinnatifida (Hawthorn Fruit, Shanzha) 

Hawthorn has long been used as a medicinal substance, and an extract such as WS 1442, a formulation of hawthorn leaves with flowers, has been evaluated in different studies for treatment of heart failure (40 2). Patients with New York Heart Association class II heart failure participated in a placebo-controlled, randomized, multicenter trial. They received 30 drops of the extract three times daily for eight weeks. At the end of the study, heart failure condition was improved (41). A meta-analysis of available clinical trials suggests that the extract is useful as an adjunct treatment for patients with mild to moderate heart failure (42). Therefore, it is likely that hawthorn products would be administered together with digoxin in clinical management of patients (Fig. 4). 

CHINESE BOTANICAL PRODUCTS AND DIGOXIN-LIKE IMMUNOREACTIVITY 

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