Bornyl toxicity

N.A. Alpha-thujone, fenchone, beta-thujone, sabinen, beyerene, bornyl acetate, camphor, borneol, sesquiterpenes, lignans, flavonoids.185-186 This herb is toxic. Against amoebas, parasites, bacteria, fungi, and viruses. 

When borneol (ROH) is fed to a dog, this toxic substance is excreted as compound P, QHgOe—OR, where R stands for the bornyl group. Compound P does not reduce Benedict s solution. It reacts with aqueous NaHC03 with the liberation of a gas. Treatment of P with aqueous acid yields borneol (ROH) and D-glucuronic acid (Table 34.1), which is oxidized by bromine water to D-glucaric acid. 

Definition Volatile oil from distillation of flowering plant Thymus vuigaris, contg. thymol, carvacrol, cymene, pinene, linalool, bornyl acetate Properties Colorless (pure) to reddish-bm. (crude) liq., pleasant thymol odor, sharp taste sol. in 2 vols 80% alcohol very si. sol. in water dens. 0.894-0.930 ref. index 1.4830-1.5100 (20 C) Toxicology LD50 (oral, rat) 2840 mg/kg mod. toxic by ing. allergen severe skin irritant ... 

---