Bone resorbing activity of la,25

The bone resorbing activities of la,25(OH)2D2 and la,25(OH)2D4 were almost the same as for la,25(OH)2D3. It is positively related to binding affinity to VDR. The results clearly explain that the calcemic effects of la,25(OH)2D2 and la,25(OH)2D4 are comparable to that of la,25(OH)2D3 as expected from their binding affinity for VDR. Sato et al. reported that bone calcium mobilization of 24-epi-la,25(OH)2D2 and la,25(OH)2D7 in vitamin D deficient rats was about 50% of that by la,25(OH)2D3 by assessing serum calcium changes after intravenous administration [36]. The results of biological activities of la,25-(OH)2D analogues were shown in Table 1 in comparison with those of l,25(OH)2D3. 

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See also in sourсe #XX -- [ , , , , ]

See also in sourсe #XX -- [ , , , ]

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