Bone cells, lycopene

The role of lycopene in bone health to date is based on its potent antioxidant properties, the well-known role of oxidative stress in bone health, and the limited reported studies on the effects of lycopene in bone cells in culture. Therefore, in order to understand the role that lycopene can play in bone health, we have included a review of the reported studies on the role of oxidative stress in bone health and bone cells. 

The effects of lycopene on osteoclast formation and bone resorption were also reported by Ishimi et al. (1999) in murine osteoclasts formed in coculture with calvarial osteoblasts (Ishimi et al., 1999). Their results differed from those of Rao et al. (2003) in that they found that lycopene inhibited the PTH-induced, but not the basal, TRAP+ multinucleated cell formation. Furthermore, they could not demonstrate any effect of lycopene on bone resorption. They also did not study the effect of lycopene on ROS production. 

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