Bogert

Purified by recrystn from glacial AcOH or from C6Hg and the yellow needles are dried in an oven at 100° until the odour of the solvent is absent. It is sparingly soluble in EtOH and Me2CO. [Bogert and Stull Org Synth Coll Vol I 220 7947 Bauer and Cymerman J Chem Soc 3434 7949.]... 

Benzoylene urea has been prepared by passing cyanogen into a solution of anthranilic acid in alcohol and hydrolyzing the resulting 2-ethoxy-4-ketodihydroquinazoline, by fusing anthranilic acid with urea, and by the action of aqueous cyanic acid on anthranilic acid. The procedure described is adapted from that of Bogert and Scatchard with several modifications. 

A series of quinazolines analogous in constitution with the angostura alkaloids has been prepared by Bogert and collaborators,... 

The Bogert synthesis of 2,4-diarylthiophenes consisting of the reaction of sulfur with the anils of arylalkyl ketones, has been shown to lead to a mixture of 2,4- and 2,5-disubstituted thiophenes. ... 

It was found inadvisable to use more than four molecules of form-amide [ (47) when R = H] per molecule of anthranilic acid and the condensation produces best results when the mixture is heated at 120 -130°C for 2 hr followed by further heating at 170°-180 C for 2 hr. Other variants of this reaction involve the use of ammonium o-acylaminobenzoates, anthranilic acid in the presence of nitriles and acetic anhydride, o-acetamidonitrile with acetic anhydride or hydrogen peroxide, anthranilic esters and aliphatic or aromatic amides or amidines, isatoic anhydride with amides or amidines, and anthranilic esters with aryl iminochlorides in acetoned The mechanism proposed by Bogert and Gotthelf has had experimental supporR and is represented in Scheme 12. 

---