Body fluids different organs

TXRF is an ideal tool for microanalysis [4.21]. The analytical merits are that TXRF has a broad range of linearity (lO -lO atoms cm ) and it is extremely surface-sensitive and matrix-independent. TXRF can be applied to a great variety of different organic and inorganic samples such as water, pure chemicals, oils, body fluids and tissues, suspended matters, etc., down to the picogram range. 

Reviews on the fate of aromatic hydrocarbons in marine organisms have been published (2,3,4). They indicated that a substantial amount of information exists on the accumulation of these compounds in a variety of phylogenetically diverse organisms. Recently, emphasis has shifted toward studies of bioconversions of these hydrocarbons. Work has been conducted on enzymes mediating the degradation of aromatic hydrocarbons and on the formation and retention of metabolites. Identifications of individual metabolites in tissues and body fluids of several marine organisms exposed to radiolabeled aromatic hydrocarbons have been made however, insufficient information is available to determine the extent of differences in metabolite profiles as evinced from chromatographic data. 

Distribution is the delivery of drug from the systemic circulation to tissues. Once a drug has entered the blood compartment, the rate at which it penetrates tissues and other body fluids depends on several factors. These include (1) capillary permeability, (2) blood flow-tissue mass ratio (i.e., perfusion rate), (3) extent of plasma protein and specific organ binding, (4) regional differences in pH, (5) transport mechanisms available, and (6) the permeability characteristics of specific tissue membranes. 

---