Body fluids alcohol ingestion

Therapeutic Concentration. Chloral hydrate is difficult to detect in body fluids after normal doses. The plasma concentration of trichloroethanol is usually in the range 1.5 to 15 pg/ml. Trichloroacetic acid and urochloralic acid are present in plasma at concentrations similar to, or greater than, those of trichloroethanol. When alcohol has been taken, peak plasma concentrations of trichloroethanol are increased and remain elevated for about 6 hours after ingestion, and those of trichloroacetic acid are decreased. Trichloroacetic acid accumulates in the plasma during chronic administration of chloral hydrate. 

P7-2Sf (Open-ended problem) You may have to look up/guess/vary some of the coo-s(ants. if methanol is ingested, it can be metabolized to formaldehyde, which can cause blindness if the formaldehyde reaches a conceniralion of 0,16 tt/dm of fluid in the body. A concentration of 0.75 g/dm will be lethal. After ail the methanol ha,s been removed from the stomach, the primary [neaimeni is to inject ethanol inirasenously to tie up (competitive inhibition) the enzyme alcohol dehydrogenase (ADH so that methanol is not converted lo formaldehyde and is eliminated from the body through the kidney and bladder (iy). We will assume as a lirsi approximation that the body is a well-mixed C.5TR of 40 dm [total body fluid i. In Section 7.5, we applied a more rigorous model-... 

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